Inside the Lab

Host Kelly Swails interviews Dr. Brad Brimhall and genetic counselor Megan Maxwell from the University of Texas Health Science Center San Antonio to discuss challenges with and strategies for the diagnosis of rare diseases. Their discussion covers topics like the advantages of proactively using genetic testing to identify gene markers at the outset of care, the possibilities of artificial intelligence in identifying markers of rare diseases, and the role of pathologists in a multi-disciplinary care team - as well as the need for adequate communication and a holistic approach within that care team. Collectively, our guests describe how these insights can be used to shorten a patient's "diagnostic odyssey."

In this special episode of Inside the Lab, producer and host David Ritter does a dive into the history of efforts to integrate AI into the practice of healthcare. He’s joined by MD/PhD candidate Rahim Hirani, who discusses the history of efforts to automate diagnostic decision making in healthcare all the way back to the 1950s, and how these efforts were qualitatively different from current tools like large language models. Then, he’s joined by Dr. Melody Nelson from the  who discusses contemporary issues with applying modern AI tools in the context of the practice of pathology.

Inside the Lab is joined by experts Drs. Hannah Wang from the Cleveland Clinic and Rodney Rohde from Texas State University to discuss emerging respiratory viruses. Their discussion begins with lessons learned from the COVID-19 pandemic and an overview of what technologies have emerged since. They go on to discuss the virology and surveillance strategies for H5N1 and RSV, as well as vaccine hesitancy and its impact in the treatment of measles. 

In this episode of Inside the Lab, Dr. Ali Brown sits down with guests Sean Tucker, MLS(ASCP)CM and Laura Severs, MHA, MLS(ASCP)CM to discuss their predictions for what 2025 holds for laboratory professionals. Topics discussed include:How workforce trends will continue in the near future and what strategies may work for addressing them;What to expect with automation and what pros and cons automation holds for Labradorians; What challenges, risks, and benefits cybersecurity holds for laboratory professionals, particular as digital pathology becomes more prevalent;What's coming with AI and what it means for the practice of laboratory medicine. 

In this episode of Inside the Lab, guests Jane Dickerson, PhD and Elise Occhipinti, MD join host Kelly Swails to discuss the creation and maintenance of laboratory test stewardship programs. Topics covered include: How and why your organization should set up a stewardship programInvolving stakeholders in the process The essential components of a success programMetrics and key performance indicators to trackResources, guidelines, and toolkits for those looking to create their own program

While the rapid evolution of I-O continues to bring unprecedented change to the way cancer is treated, there are significant gaps impacting the laboratory team regarding the examination of resection specimens following neoadjuvant immunotherapy and staying abreast of advances in I-O biomarker testing. This episode discusses advances in I-O biomarker testing, advantages and limitations of some key I-O biomarkers, and practical ways that pathologists and laboratory professionals can improve their I-O biomarker testing workflows to optimize patient care. Topics discussed include: Recent advances in immune-oncology (I-O) biomarker testing Advantages and limitations of IO biomarkers Addressing challenges related to IO biomarkers Improving IO biomarker workflows Best practices for collaboration with the multidisciplinary cancer care team 

The diagnostic paradigm for Alzheimer's disease (AD) has rapidly shifted in the last five years as fluid-based biomarker testing has emerged as a reliable, accurate, and accessible means to detect amyloid pathology when evaluating a patient for cognitive decline. This podcast is designed to help pathologists and laboratory professionals gain an understanding of plasma testing for markers such as Abeta40/42, P-tau181, and P-tau217 which are rapidly appearing in the commercial space and how healthcare providers have begun incorporating these tests into routine neurology practice. This podcast will help participants to understand the advantages and limitations of these assays as well as their potential application when a physician is evaluating a patient for AD. 

Communicating imperative diagnoses effectively can often be a daunting challenge. It’s a crucial and delicate step that takes practice and know-how to do well and can be one of the most important actions taken with patients. That’s why a panel of experts have gotten together to discuss the current practices, gaps, and best practices for communication of urgent and significant/unexpected diagnoses in anatomic pathology.The Promoting Diagnostic Excellence by Improving the Communication of Urgent and Unexpected Diagnoses in Anatomic Pathology podcast is designed to support the collaboration with clinical partners as well as to notice actionable opportunities where the communication of urgent and significant/unexpected diagnoses in anatomic pathology may be improved.You will learn to:Understand current guidelines and practices for communication of urgent and unexpected diagnosis in anatomic pathology. Discuss high-priority communication barriers.Discuss best practices and recommendations for effective and timely communication of urgent and significant/unexpected diagnoses. 

Women make up a majority of the workforce in pathology yet lag behind men in leadership roles. What are the consequences of this for women working in pathology today, and what can be done?  In this episode of Inside the Lab, Drs. Melissa Upton and Kimberly Sanford share a warm conversation in which they reflect on their long and varied careers, describe the unique challenges they faced over their careers, and discuss their accomplishments as trailblazers themselves. Our guests describe the value of finding mentors,  They also describe the opportunities for the future of pathology, particularly in the context of working in a multigenerational workforce with evolving expectations of workplace culture.

Although molecular testing offers promising opportunities for diagnosis and targeted treatment of cancers, prostate cancer has lagged behind other types of cancer. Recently, homologous recombination repair testing in prostate cancer has provided a means to achieving targeted treatments for patients as well as opening new avenues of collaboration between pathologists and oncologists.On this episode of Inside the Lab, hosts Ms. Kelly Swails, MLS(ASCP), and Dr. Ali Brown, MD, FASCP are joined by Heather Cheng, a medical oncologist and associate professor of hematology and oncology at the University of Washington and Fred Hutchinson Cancer Center, and Colin Pritchard, molecular pathologist and professor of laboratory science and director of the Genetics and Solid Tumors Laboratory at the University of Washington Medical Center.Our panelists discuss the current treatment landscape for prostate cancer and how HRR testing can improve patient outcomes in this context.Topics Covered  An introduction to metastatic prostate cancer testing, and what types of tests are standard of care, and the rationale for targeting prostate cancer using PARPKey findings from recent phase III randomized clinical trialsStandards for optimal testing in prostate cancer, particularly concerning sample sources and the choice between next-generation sequencing (NGS) and polymerase chain reaction (PCR) methodscommon pitfalls or challenges in the arena of accurately reporting and interpreting findings from HRR testsPractical tips for optimal coordination among a multidisciplinary, cross-departmental team of healthcare providers and laboratory professionals when utilizing HRR testing in prostate cancer management.Connect with ASCPASCPASCP on FacebookASCP on InstagramASCP on Twitter Connect with Dr. ChengDr. Cheng on LinkedIn Connect with Dr. PritchardDr. Pritchard Connect with Ms. Swails & Dr. BrownMs. Swails on TwitterDr. Brown on Twitter ResourcesASCP Membership 2024Proposed FDA Regulation of Laboratory Developed TestsPublic Comment on the FDA’s Proposed RuleInside the Lab in the ASCP Store